Key countries in the Indo-Pacific region have led global economic activities due to their economic interdependence within and outside the region. Nowadays, they are faced with grave challenges amid the rising geopolitical and geo-economic tensions within the region. The trends of de-globalization are threatening to weaken regional economic interdepence, against which major countries in the region have been adopting new trade and industrial policies with economic security purposes. Are there ways to make economic interdepence and economic security compatible and co-exist within the region? This session aims to address this fundamental question in order to suggest ways to coordinate the region’s policies toward a more coherent economic security policy direction.